rna polymerase iii transcription
| PAG Title | rna polymerase iii transcription |
| PAG ID | WAG000654 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Unlike the R polymerase II that transcribes a large variety of genes that encode proteins, R polymerase III transcribes only a limited number of genes (i.e., 5S rR. tR. 7SL R, U6 snR and a few other small stable Rs); however, the transcriptiol activities of R pol III along with pol I account for 80% of total R synthesis. The A and B block sequences found in most pol III promoters is recognized by a multisubunit complex, TFIIIC. The binding of TFIIIC recruits TFIIIB, a complex of polypeptides (in human, TATA-binding protein (TBP), TFIIB-related factor (BRF), and one or more unidentified protein). Once TFIIIB is brought to the general location by TFIIIC and optimally positioned by TBP, the transcription initiates about 30bp downstream. The transcription process requires the melting of dsD and participation of TFIIIB. Unlike pol I and II, pol III termition occurs efficiently at four or more T residues without other protein factors. La protein can stimulate the release of R and pol III transcription; however, deletion of La has no apparent effect on pol III activity. |
| Species | Homo sapiens |
| nCoCo Score | 851 |
| Base PAG ID | WAG000654 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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